Vascular Endothelial Growth Factor in Diabetic Complications

Vascular Endothelial Growth Factor (VEGF) plays a crucial role in angiogenesis, but in diabetes, its dysregulation is linked to complications such as diabetic retinopathy and nephropathy. High levels of VEGF in diabetic patients stimulate abnormal blood vessel growth, contributing to retinal damage and vision loss in retinopathy. In the kidneys, overexpression of VEGF can exacerbate glomerular damage, accelerating diabetic nephropathy. Therapeutic targeting of VEGF with inhibitors is being explored to prevent excessive angiogenesis in diabetic complications, particularly in managing retinopathy, where anti-VEGF therapies have shown promise in preserving vision.