Title : Vascular dysfunction and diabetes mellitus: a pathophysiological association
Abstract:
Points of Discussion: Prevalence of Diabetes, Effect of Diabetes on vascular dysfunction, Biomarkers targeting vascular dysfunction in diabetic condition, possible treatments.
There are around 100 million people worldwide who have diabetes mellitus. 5% to 10% of people have type 1 diabetes, also known as insulin-dependent diabetes, while 90% to 95% have type 2 diabetes, also known as non-insulin-dependent diabetes. As a result of lifestyle choices causing obesity, type 2 diabetes incidence is probably going to increase. As vascular disorders are the leading causes of mortality and disability among diabetics, cardiovascular specialists are seeing a lot of these patients. Atherosclerosis and medial calcification are examples of the macrovascular manifestations. Retinopathy and nephropathy, which are microvascular sequelae, are significant contributors to blindness and end-stage renal failure. To best treat these patients, doctors must be aware of the key characteristics of diabetic vascular disease.
In a healthy state, endogenous reparative activities reduce endothelial cell damage. Patients with diabetes have an imbalance between repair and damage, which causes micro-vascular alterations, including micro-vascular cell death, which eventually culminates in problems from diabetes. Changes in proliferation, barrier function, adherence of other circulating cells, and susceptibility to apoptosis are indicative of endothelial dysfunction in diabetes mellitus. The angiogenic and synthetic capacities of endothelial cells may also be altered by diabetes mellitus.
Research on biomarkers is also pacing up to find out some innovative combinations or target molecules to be treated as biomarkers and is capable of showing it’s efficiency throughout the course of the disease.
In her talk the speaker will focus on the Prevalence of Diabetes, Effect of Diabetes on vascular dysfunction.
Biomarkers targeting vascular dysfunction in diabetic condition and possible treatments
Audience Takeaway:
- Through this talk the research and student community will understand the significance of endothelium and it’s direct involvement in peripheral vascular disease.
- They will understand Dysfunction of the vascular endothelium is a hallmark of human diseases and hence will apply the concept in their advanced research assignments.
- Targeting the biomarkers/changing parameters could be used in the development/discovery of biomarkers in vascular diseases.
