Title : The association dietary inflammatory index with breast cancer: A case-control study
Abstract:
Due to the lack of studies, the purpose of this study is to realize the association between the energy-adjusted dietary inflammatory index (EDII) and tumor size and grade, proliferation marker (KI67), and odd of BC.
Methods: This study included 165 BC patients and 166 healthy women, where EDII scores were determined based on a comprehensive 147-item food frequency questionnaire (FFQ). Statistical analyses, such as one-way ANOVA, chi-square tests, linear regression models, Spearman Correlation Coefficient test, and multivariable logistic regression analysis, were utilized to investigate these associations.
Results: We found significant associations between the EDII score and tumor size (r=0.1, r=0.24, p=0.001 respectively), and histological grade in all models (r=0.22, 0.23 ; p=0.003, 0.004 respectively). Nevertheless, the association between the EDII score and tumor stage was significant in model 1 and 2 (r=0.18, 0.17 ; p=0.01, 0.02 respectively), but not in model 3 (r=0.08; p=0.29). Also, a positive but not significant association between the EDII score and KI67 was demonstrated in all models (p>0.05). At last, in the crude and adjusted model for various confounders, there was no significant association between EDII and BC odds (p>0.05)
Conclusions: There was a significant association between the EDII score and tumor size and histological grade in all models and tumor stage, in the crude and adjusted model. The study results add new insight into the association between EDII and prognosis and pathological biomarkers of BC patients. Future research employing prospective study designs is essential to rigorously evaluate the proposed hypothesis in greater detail.
Keywords: Cancer Biomarkers, Women's Health, Tumor Biology, KI67 ,Proliferation Index, Histopathological Grade
