The complex interplay between metabolic dysregulation and neural function highlights the neurological effects of diabetes, affecting both the central and peripheral nervous systems. Chronic hyperglycemia leads to oxidative stress and inflammatory responses, contributing to cognitive decline, increased stroke risk, and autonomic dysfunction. Peripheral neuropathy manifests as numbness, tingling, or pain, while autonomic neuropathy impairs cardiovascular, gastrointestinal, and urogenital functions. Emerging research suggests that insulin resistance and mitochondrial dysfunction may accelerate neurodegeneration, linking diabetes to conditions like Alzheimer's disease. Advances in neuroprotective strategies, including targeted pharmacotherapy, glycemic control, and lifestyle interventions, are essential for mitigating these effects and preserving neural health in diabetic patients.
Mahir Khalil Ibrahim Jallo
Gulf Medical University, Canada
Yong Xiao Wang
Albany Medical College, United States
F Buck Willis
Belize Bible College, Belize
Sujith Rajan
NYU Long Island School of Medicine, United States
Amy Gutman
AdventHealth; Tough Love MD, United States
Paraskevi Theofilou
Hellenic Open University, Greece
Teji S Dhami
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