Hormonal imbalances originating from the pituitary and adrenal gland disorders significantly affect metabolic regulation, stress response, and glucose homeostasis. Conditions such as Cushing’s syndrome, Addison’s disease, and acromegaly disrupt normal endocrine signaling, contributing to insulin resistance, hypertension, and cardiovascular complications. Advances in endocrinology have led to targeted therapies, including hormone replacement and receptor-specific drugs, to restore balance. Imaging technologies and molecular diagnostics have improved early detection, allowing for timely interventions. Understanding the connections between pituitary-adrenal dysfunction and metabolic diseases enables the development of more precise treatment strategies. Ongoing research continues to refine therapeutic options, offering new hope for patients with complex endocrine disorders.
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