The intersection of reproductive endocrinology & women's health with diabetes presents unique challenges across different life stages. Polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) are common metabolic disorders linked to insulin resistance, affecting fertility and pregnancy outcomes. Hormonal fluctuations influence glycemic control, making diabetes management more complex during puberty, pregnancy, and menopause. Emerging research highlights the impact of sex hormones on glucose metabolism and the role of individualized treatment approaches in optimizing reproductive health. Advancements in assisted reproductive technologies, targeted hormonal therapies, and lifestyle interventions improve fertility outcomes and maternal health. A comprehensive approach integrating endocrinology, obstetrics, and metabolic management is essential for addressing these challenges effectively.