Risk and Benefit of New Therapies

Individualization of care with careful medication selection is increasingly recognized as one of the foundations of care for diabetes, which is not a disease of "one size fits all." The amount of time spent in a condition of hyperglycemia has long been known to raise the risk of complications. Hyperglycemia can leave a negative "metabolic memory" on cells of the vasculature and target organs, encouraging the development of difficulties in the future. Despite the necessity of meeting proper glycemic targets, there is still a gap between the goals specified and the goals achieved. Failure to commence or intensify treatment in a timely manner in persons whose health is expected to improve with this intensification is referred to as clinical inertia