Hepatic Fibrosis in Diabetes

Hepatic fibrosis is a progressive liver disease characterized by excessive accumulation of extracellular matrix proteins, leading to scarring and impaired liver function. In individuals with diabetes, particularly Type 2, there is a strong association with non-alcoholic fatty liver disease (NAFLD), which can progress to fibrosis. Insulin resistance, hyperglycemia, and dyslipidemia contribute to the development of hepatic fibrosis by promoting inflammation and oxidative stress within the liver. Early detection and management of hepatic fibrosis are crucial, as they can significantly impact diabetes outcomes and increase the risk of liver-related complications. Treatment strategies may include lifestyle modifications, metabolic control, and emerging antifibrotic therapies aimed at halting disease progression and preserving liver function.