Hepatocyte Function in Diabetic Patients

Hepatocytes, the functional cells of the liver, play a critical role in glucose metabolism. In diabetes, hepatocyte function is often impaired, leading to disrupted glucose homeostasis. Insulin resistance reduces the liver's ability to store glucose as glycogen, resulting in increased glucose production and release into the bloodstream, worsening hyperglycemia. Additionally, excess fat accumulation in hepatocytes (hepatic steatosis) is common in type 2 diabetes, contributing to non-alcoholic fatty liver disease (NAFLD). This condition further impairs liver function and increases the risk of cardiovascular disease. Proper diabetes management is crucial to protecting liver health and preventing complications.